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A hypodermic needle, one of a category of medical tools which enter the skin, called sharps, is a very thin, hollow tube with a sharp tip that contains a small opening at the pointed end. It is commonly used with a syringe, a hand-operated device with a plunger, to inject substances into the body or extract fluids from the body. They are used to take liquid samples from the body, for example taking blood from a vein in veinpuncture. Large bore hypodermic intervention is especially useful in catastrophic blood loss or treating shock.

A hypodermic needle is used for rapid delivery of liquids, or when the injected substance cannot be ingested. There are many possible routes for an injection, with the arm being a common location.

The hypodermic needle also serves an important role in research environments where sterile conditions are required. The hypodermic needle significantly reduces contamination during inoculation of a sterile substrate. The hypodermic needle reduces conta            mination for two reasons: First, its surface is extremely smooth, which prevents airborne pathogens from becoming trapped between irregularities on the needle's surface, which would subsequently be transferred into the media (e.g. agar) as contaminants; second, the needle's surface is extremely sharp, which significantly reduces the diameter of the hole remaining after puncturing the membrane and consequently prevents microbes larger than this hole from contaminating the substrate